Drug interactions
Dipipanone + Phenelzine
Severity: Major
Dipipanone and Phenelzine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids given with MAOIs can cause unpredictable reactions, including serotonin-like toxicity, profound sedation, respiratory depression, and swings in blood pressure. Dipipanone is related to methadone and pethidine, so similar risks are expected.
What this interaction means in plain words
Dipipanone and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Probably serotonergic excess and potentiated CNS depression in the presence of MAO inhibition; not fully defined.
What to do
Avoid dipipanone in patients taking an MAOI or within 14 days of stopping it. Choose an alternative analgesic and monitor respiration and blood pressure if an opioid is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Dipipanone with Phenelzine?
MediHelp rates the interaction as major. Dipipanone and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids given with MAOIs can cause unpredictable reactions, including serotonin-like toxicity, profound sedation, respiratory depression, and swings in blood pressure. Dipipanone is related to methadone and pethidine, so similar risks are expected.
How serious is the interaction between Dipipanone and Phenelzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid dipipanone in patients taking an MAOI or within 14 days of stopping it. Choose an alternative analgesic and monitor respiration and blood pressure if an opioid is unavoidable.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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