Drug interactions
Dipipanone + Selegiline
Severity: Major
Dipipanone and Selegiline: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids given with MAO inhibitors can cause serious reactions, including severe sedation, respiratory depression, hypotension or serotonin-like hyperthermia. Selegiline, especially transdermal, increases the concern.
What this interaction means in plain words
Dipipanone and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression and possible serotonergic effects with MAO inhibition; mechanism not established.
What to do
Avoid the combination and choose an alternative analgesic. If unavoidable, use low doses and monitor respiration, temperature and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Dipipanone with Selegiline?
MediHelp rates the interaction as major. Dipipanone and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids given with MAO inhibitors can cause serious reactions, including severe sedation, respiratory depression, hypotension or serotonin-like hyperthermia. Selegiline, especially transdermal, increases the concern.
How serious is the interaction between Dipipanone and Selegiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative analgesic. If unavoidable, use low doses and monitor respiration, temperature and blood pressure.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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