Drug interactions
Dipyridamole + Ginkgo biloba
Severity: Moderate
Dipyridamole and Ginkgo biloba: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ginkgo biloba extracts inhibit platelet-activating factor and may enhance the antiplatelet effect of dipyridamole. Case reports of bleeding exist with ginkgo, though controlled data are conflicting.
What this interaction means in plain words
Dipyridamole and Ginkgo biloba can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects through platelet-activating factor antagonism by ginkgolides plus dipyridamole's adenosine reuptake and phosphodiesterase inhibition.
What to do
Advise patients to avoid ginkgo while taking dipyridamole, especially if other antiplatelets or anticoagulants are also used. Monitor for bruising, bleeding and unexplained anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Frequently asked questions
Can I take Dipyridamole with Ginkgo biloba?
MediHelp rates the interaction as moderate. Dipyridamole and Ginkgo biloba can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ginkgo biloba extracts inhibit platelet-activating factor and may enhance the antiplatelet effect of dipyridamole. Case reports of bleeding exist with ginkgo, though controlled data are conflicting.
How serious is the interaction between Dipyridamole and Ginkgo biloba?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid ginkgo while taking dipyridamole, especially if other antiplatelets or anticoagulants are also used. Monitor for bruising, bleeding and unexplained anemia.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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