Drug interactions
Dipyridamole + Glecaprevir / pibrentasvir
Severity: Minor
Dipyridamole and Glecaprevir / pibrentasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-gp and BCRP, so they may raise dipyridamole exposure. Dipyridamole may in turn modestly raise levels of the antivirals through transporter inhibition. Clinical effects are predicted from transporter data, not well documented.
What this interaction means in plain words
Dipyridamole and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mutual inhibition of P-gp and BCRP transporters may increase exposure to both medications.
What to do
No empirical dose change is needed; monitor for dipyridamole adverse effects such as hypotension and headache during the antiviral course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Frequently asked questions
Can I take Dipyridamole with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as minor. Dipyridamole and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-gp and BCRP, so they may raise dipyridamole exposure. Dipyridamole may in turn modestly raise levels of the antivirals through transporter inhibition. Clinical effects are predicted from transporter data, not well documented.
How serious is the interaction between Dipyridamole and Glecaprevir / pibrentasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for dipyridamole adverse effects such as hypotension and headache during the antiviral course.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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