Drug interactions
Dipyridamole + Selumetinib
Severity: Moderate
Dipyridamole and Selumetinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selumetinib has been associated with hemorrhage, and its labeling cautions about antiplatelet agents. Dipyridamole has antiplatelet activity, so the combination may modestly increase bleeding risk.
What this interaction means in plain words
Dipyridamole and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dipyridamole belongs to Cardiovascular; Selumetinib belongs to Oncology.
Why it happens
Additive bleeding tendency from antiplatelet effect of dipyridamole and selumetinib-associated hemorrhage.
What to do
Monitor for bleeding and hemoglobin during co-use. Reassess the combination if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Other interactions of Selumetinib
Frequently asked questions
Can I take Dipyridamole with Selumetinib?
MediHelp rates the interaction as moderate. Dipyridamole and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selumetinib has been associated with hemorrhage, and its labeling cautions about antiplatelet agents. Dipyridamole has antiplatelet activity, so the combination may modestly increase bleeding risk.
How serious is the interaction between Dipyridamole and Selumetinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and hemoglobin during co-use. Reassess the combination if bleeding occurs.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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