Drug interactions
Disulfiram + Isocarboxazid
Severity: Moderate
Disulfiram and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Delirium and psychotic reactions have been described when disulfiram is combined with MAOIs. Although evidence is limited, the neuropsychiatric risk is potentially serious.
What this interaction means in plain words
Disulfiram and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Not established; possibly altered catecholamine metabolism from combined enzyme inhibition.
What to do
Avoid combining if possible, otherwise monitor mental status closely and stop disulfiram if confusion or psychosis emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Disulfiram with Isocarboxazid?
MediHelp rates the interaction as moderate. Disulfiram and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Delirium and psychotic reactions have been described when disulfiram is combined with MAOIs. Although evidence is limited, the neuropsychiatric risk is potentially serious.
How serious is the interaction between Disulfiram and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if possible, otherwise monitor mental status closely and stop disulfiram if confusion or psychosis emerges.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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