Drug interactions
Disulfiram + Meloxicam
Severity: Minor
Disulfiram and Meloxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram inhibits several CYP enzymes, including CYP2C9, which is the main route of meloxicam metabolism. Meloxicam exposure may increase, raising the chance of NSAID adverse effects such as GI bleeding and renal impairment.
What this interaction means in plain words
Disulfiram and Meloxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP2C9-mediated meloxicam metabolism.
What to do
Use the lowest effective meloxicam dose and monitor for GI and renal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Disulfiram with Meloxicam?
MediHelp rates the interaction as minor. Disulfiram and Meloxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Disulfiram inhibits several CYP enzymes, including CYP2C9, which is the main route of meloxicam metabolism. Meloxicam exposure may increase, raising the chance of NSAID adverse effects such as GI bleeding and renal impairment.
How serious is the interaction between Disulfiram and Meloxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective meloxicam dose and monitor for GI and renal adverse effects.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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