Drug interactions
Disulfiram + Paracetamol
Severity: Minor
Disulfiram and Paracetamol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram inhibits CYP2E1, which would be expected to reduce formation of the toxic paracetamol metabolite rather than increase toxicity. No clinically important effect has been established.
What this interaction means in plain words
Disulfiram and Paracetamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Disulfiram inhibits CYP2E1, which may alter paracetamol oxidative metabolism.
What to do
No dose adjustment is needed; use paracetamol at standard doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paracetamol
- Ethanol + Paracetamol Major
- Busulfan + Paracetamol Moderate
- Carbamazepine + Paracetamol Moderate
- Cholestyramine + Paracetamol Moderate
- Felbamate + Paracetamol Moderate
- Fosphenytoin + Paracetamol Moderate
Frequently asked questions
Can I take Disulfiram with Paracetamol?
MediHelp rates the interaction as minor. Disulfiram and Paracetamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Disulfiram inhibits CYP2E1, which would be expected to reduce formation of the toxic paracetamol metabolite rather than increase toxicity. No clinically important effect has been established.
How serious is the interaction between Disulfiram and Paracetamol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; use paracetamol at standard doses.
What other medicines interact with Paracetamol?
MediHelp also lists interactions of Paracetamol with, for example, Ethanol, Busulfan, Carbamazepine. The full list is on the Paracetamol page.
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