Drug interactions
Felbamate + Paracetamol
Severity: Moderate
Felbamate and Paracetamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate may induce metabolism of paracetamol, increasing formation of the hepatotoxic metabolite NAPQI and lowering parent drug levels. Evidence is limited, and the risk is mainly relevant with high or prolonged paracetamol use, particularly as felbamate itself carries hepatotoxicity risk.
What this interaction means in plain words
Felbamate and Paracetamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felbamate belongs to Central Nervous System; Paracetamol belongs to Musculoskeletal.
Why it happens
Felbamate enhances hepatic metabolism of paracetamol, increasing production of toxic metabolites.
What to do
Keep paracetamol at the lowest effective dose and monitor liver function in patients on felbamate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paracetamol
- Ethanol + Paracetamol Major
- Busulfan + Paracetamol Moderate
- Carbamazepine + Paracetamol Moderate
- Cholestyramine + Paracetamol Moderate
- Fosphenytoin + Paracetamol Moderate
- Imatinib + Paracetamol Moderate
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Paracetamol?
MediHelp rates the interaction as moderate. Felbamate and Paracetamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate may induce metabolism of paracetamol, increasing formation of the hepatotoxic metabolite NAPQI and lowering parent drug levels. Evidence is limited, and the risk is mainly relevant with high or prolonged paracetamol use, particularly as felbamate itself carries hepatotoxicity risk.
How serious is the interaction between Felbamate and Paracetamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep paracetamol at the lowest effective dose and monitor liver function in patients on felbamate.
What other medicines interact with Paracetamol?
MediHelp also lists interactions of Paracetamol with, for example, Ethanol, Busulfan, Carbamazepine. The full list is on the Paracetamol page.
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