Drug interactions
Divalproex + Zuranolone
Severity: Major
Divalproex and Zuranolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes marked somnolence and driving impairment, and valproate adds further CNS depression. Together they may increase sedation and psychomotor impairment.
What this interaction means in plain words
Divalproex and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depressant pharmacodynamic effects at GABAergic pathways.
What to do
Consider reducing the zuranolone dose and warn patients not to drive for at least 12 hours after each dose. Monitor for excessive sedation and confusion.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Divalproex with Zuranolone?
MediHelp rates the interaction as major. Divalproex and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Zuranolone causes marked somnolence and driving impairment, and valproate adds further CNS depression. Together they may increase sedation and psychomotor impairment.
How serious is the interaction between Divalproex and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the zuranolone dose and warn patients not to drive for at least 12 hours after each dose. Monitor for excessive sedation and confusion.
What other medicines interact with Zuranolone?
MediHelp also lists interactions of Zuranolone with, for example, Alprazolam, Amobarbital, Apalutamide. The full list is on the Zuranolone page.
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