Drug interactions
Dobutamine + Hydrochlorothiazide-olmesartan
Severity: Moderate
Dobutamine and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine, through beta-2 stimulation, can shift potassium into cells and lower serum potassium. Together with the thiazide, hypokalemia may be more pronounced, raising arrhythmia risk in acutely ill patients.
What this interaction means in plain words
Dobutamine and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Beta-adrenergic intracellular potassium shift adds to thiazide-induced renal potassium loss.
What to do
Monitor serum potassium during dobutamine infusion and replace potassium as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Dobutamine and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine, through beta-2 stimulation, can shift potassium into cells and lower serum potassium. Together with the thiazide, hypokalemia may be more pronounced, raising arrhythmia risk in acutely ill patients.
How serious is the interaction between Dobutamine and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during dobutamine infusion and replace potassium as required.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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