Drug interactions
Dobutamine + Levosalbutamol
Severity: Moderate
Dobutamine and Levosalbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are beta-adrenergic agonists, so combined use can intensify tachycardia, arrhythmias, blood pressure changes and hypokalemia. This is relevant in patients with heart failure or ischemic disease receiving dobutamine infusions.
What this interaction means in plain words
Dobutamine and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Levosalbutamol belongs to Respiratory.
Why it happens
Additive beta-adrenergic stimulation, with beta-2 mediated intracellular potassium shift causing hypokalemia.
What to do
Monitor ECG, heart rate, blood pressure and serum potassium during dobutamine infusion. Avoid unnecessary or high-dose levosalbutamol and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Levosalbutamol?
MediHelp rates the interaction as moderate. Dobutamine and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are beta-adrenergic agonists, so combined use can intensify tachycardia, arrhythmias, blood pressure changes and hypokalemia. This is relevant in patients with heart failure or ischemic disease receiving dobutamine infusions.
How serious is the interaction between Dobutamine and Levosalbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate, blood pressure and serum potassium during dobutamine infusion. Avoid unnecessary or high-dose levosalbutamol and correct hypokalemia.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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