Drug interactions
Dobutamine + Metaproterenol
Severity: Moderate
Dobutamine and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol is a beta agonist that causes tachycardia and hypokalemia. Combined with dobutamine, these effects are additive and may provoke arrhythmias or myocardial ischemia.
What this interaction means in plain words
Dobutamine and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-adrenergic agonism, including beta-2 mediated potassium shift into cells.
What to do
Monitor ECG, heart rate and serum potassium, and replace potassium as needed. Lower the infusion rate if arrhythmias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Metaproterenol?
MediHelp rates the interaction as moderate. Dobutamine and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaproterenol is a beta agonist that causes tachycardia and hypokalemia. Combined with dobutamine, these effects are additive and may provoke arrhythmias or myocardial ischemia.
How serious is the interaction between Dobutamine and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and serum potassium, and replace potassium as needed. Lower the infusion rate if arrhythmias develop.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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