Drug interactions
Dobutamine + Olodaterol inhaled
Severity: Moderate
Dobutamine and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olodaterol is a long-acting beta-2 agonist and dobutamine is a beta-1 predominant inotrope, so together they can amplify tachycardia, blood pressure rises and arrhythmia risk. Some systemic absorption of inhaled olodaterol occurs, and hypokalemia may also be worsened.
What this interaction means in plain words
Dobutamine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta-adrenergic receptor stimulation producing cardiovascular and metabolic effects.
What to do
Monitor heart rate, rhythm, blood pressure and serum potassium during dobutamine infusion in patients using olodaterol. Reduce the dobutamine rate if tachyarrhythmias occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Dobutamine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olodaterol is a long-acting beta-2 agonist and dobutamine is a beta-1 predominant inotrope, so together they can amplify tachycardia, blood pressure rises and arrhythmia risk. Some systemic absorption of inhaled olodaterol occurs, and hypokalemia may also be worsened.
How serious is the interaction between Dobutamine and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm, blood pressure and serum potassium during dobutamine infusion in patients using olodaterol. Reduce the dobutamine rate if tachyarrhythmias occur.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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