Drug interactions
Dobutamine + Promazine
Severity: Moderate
Dobutamine and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine is a phenothiazine with alpha-blocking and QT-prolonging properties. With dobutamine, vasodilation may cause hypotension with reflex tachycardia, and arrhythmia risk may increase in susceptible patients.
What this interaction means in plain words
Dobutamine and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha-adrenergic blockade and QT prolongation by promazine combined with dobutamine's proarrhythmic beta stimulation.
What to do
Monitor ECG, QTc and blood pressure, and correct potassium and magnesium. Reduce the dobutamine rate if arrhythmias or marked hypotension occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Promazine?
MediHelp rates the interaction as moderate. Dobutamine and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine is a phenothiazine with alpha-blocking and QT-prolonging properties. With dobutamine, vasodilation may cause hypotension with reflex tachycardia, and arrhythmia risk may increase in susceptible patients.
How serious is the interaction between Dobutamine and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, QTc and blood pressure, and correct potassium and magnesium. Reduce the dobutamine rate if arrhythmias or marked hypotension occur.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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