Drug interactions
Dobutamine + Selegiline transdermal
Severity: Moderate
Dobutamine and Selegiline transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine is a catecholamine that is mainly metabolized by COMT and not significantly by MAO, so the interaction is less pronounced than with indirect sympathomimetics. Transdermal selegiline at higher doses can lose MAO-B selectivity, however, and may enhance pressor responses to sympathomimetics. A hypertensive reaction is possible but not well documented for dobutamine.
What this interaction means in plain words
Dobutamine and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible potentiation of sympathomimetic pressor effects through MAO inhibition by non-selective selegiline.
What to do
Start dobutamine at a low dose and titrate carefully while monitoring blood pressure and heart rate. Stop the infusion or reduce the rate if a hypertensive response occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dobutamine and Selegiline transdermal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Selegiline transdermal?
MediHelp rates the interaction as moderate. Dobutamine and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine is a catecholamine that is mainly metabolized by COMT and not significantly by MAO, so the interaction is less pronounced than with indirect sympathomimetics. Transdermal selegiline at higher doses can lose MAO-B selectivity, however, and may enhance pressor responses to sympathomimetics. A hypertensive reaction is possible but not well documented for dobutamine.
How serious is the interaction between Dobutamine and Selegiline transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start dobutamine at a low dose and titrate carefully while monitoring blood pressure and heart rate. Stop the infusion or reduce the rate if a hypertensive response occurs.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
