Drug interactions
Dobutamine + Yohimbe
Severity: Major
Dobutamine and Yohimbe: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine increases sympathetic outflow through alpha-2 blockade, raising blood pressure and heart rate. With dobutamine, this may cause an exaggerated hypertensive or tachycardic response. Supplement potency is variable.
What this interaction means in plain words
Dobutamine and Yohimbe can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive sympathomimetic effects from increased norepinephrine release plus direct beta-adrenergic agonism.
What to do
Avoid yohimbe in patients needing dobutamine. If recent use is known, monitor blood pressure and heart rate and use lower starting infusion rates.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Yohimbe?
MediHelp rates the interaction as major. Dobutamine and Yohimbe can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Yohimbine increases sympathetic outflow through alpha-2 blockade, raising blood pressure and heart rate. With dobutamine, this may cause an exaggerated hypertensive or tachycardic response. Supplement potency is variable.
How serious is the interaction between Dobutamine and Yohimbe?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yohimbe in patients needing dobutamine. If recent use is known, monitor blood pressure and heart rate and use lower starting infusion rates.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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