Drug interactions
Dobutamine + Yohimbine
Severity: Moderate
Dobutamine and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine blocks alpha-2 adrenoceptors and increases noradrenergic outflow, raising blood pressure and heart rate. With dobutamine, additive sympathetic stimulation can cause hypertension, tachycardia and arrhythmia.
What this interaction means in plain words
Dobutamine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation: alpha-2 antagonism by yohimbine plus direct beta-agonism by dobutamine.
What to do
Monitor blood pressure, heart rate and ECG during dobutamine infusion if yohimbine has been taken. Reduce the dobutamine rate if hypertension or arrhythmias occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dobutamine
Frequently asked questions
Can I take Dobutamine with Yohimbine?
MediHelp rates the interaction as moderate. Dobutamine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine blocks alpha-2 adrenoceptors and increases noradrenergic outflow, raising blood pressure and heart rate. With dobutamine, additive sympathetic stimulation can cause hypertension, tachycardia and arrhythmia.
How serious is the interaction between Dobutamine and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG during dobutamine infusion if yohimbine has been taken. Reduce the dobutamine rate if hypertension or arrhythmias occur.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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