Drug interactions
Docetaxel + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Major
Docetaxel and Elvitegravir / cobicistat / emtricitabine / tenofovir df: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Docetaxel is mainly metabolized by CYP3A4, so cobicistat can markedly increase its exposure. This can cause severe neutropenia, mucositis, fluid retention and hepatic toxicity.
What this interaction means in plain words
Docetaxel and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cobicistat inhibits CYP3A4 and P-glycoprotein, reducing docetaxel clearance.
What to do
Avoid the combination if possible by switching to an unboosted antiretroviral regimen. If unavoidable, monitor blood counts closely and consider docetaxel dose reduction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Docetaxel
Frequently asked questions
Can I take Docetaxel with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as major. Docetaxel and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Docetaxel is mainly metabolized by CYP3A4, so cobicistat can markedly increase its exposure. This can cause severe neutropenia, mucositis, fluid retention and hepatic toxicity.
How serious is the interaction between Docetaxel and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible by switching to an unboosted antiretroviral regimen. If unavoidable, monitor blood counts closely and consider docetaxel dose reduction.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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