Drug interactions
Docetaxel + Fosphenytoin
Severity: Moderate
Docetaxel and Fosphenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosphenytoin is converted to phenytoin, a CYP3A4 inducer that can increase docetaxel clearance. Reduced docetaxel exposure may compromise antitumour efficacy.
What this interaction means in plain words
Docetaxel and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Fosphenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4 and possibly P-glycoprotein, increasing docetaxel elimination.
What to do
Switch to a non-inducing anticonvulsant where possible. Otherwise monitor tumour response and docetaxel tolerance, and check phenytoin levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Docetaxel with Fosphenytoin?
MediHelp rates the interaction as moderate. Docetaxel and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosphenytoin is converted to phenytoin, a CYP3A4 inducer that can increase docetaxel clearance. Reduced docetaxel exposure may compromise antitumour efficacy.
How serious is the interaction between Docetaxel and Fosphenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Switch to a non-inducing anticonvulsant where possible. Otherwise monitor tumour response and docetaxel tolerance, and check phenytoin levels.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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