Drug interactions
Docetaxel + Glecaprevir / pibrentasvir
Severity: Moderate
Docetaxel and Glecaprevir / pibrentasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase docetaxel exposure. Increased myelosuppression and other toxicities are possible.
What this interaction means in plain words
Docetaxel and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein (and possibly other transporters) reduces docetaxel efflux and clearance.
What to do
Monitor blood counts and docetaxel adverse effects during overlap, and consider docetaxel dose reduction if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Frequently asked questions
Can I take Docetaxel with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as moderate. Docetaxel and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-glycoprotein and may increase docetaxel exposure. Increased myelosuppression and other toxicities are possible.
How serious is the interaction between Docetaxel and Glecaprevir / pibrentasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and docetaxel adverse effects during overlap, and consider docetaxel dose reduction if toxicity occurs.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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