Drug interactions
Docetaxel + Griseofulvin
Severity: Moderate
Docetaxel and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may lower docetaxel exposure and reduce its antitumor effect. The magnitude is uncertain.
What this interaction means in plain words
Docetaxel and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Griseofulvin belongs to Anti Fungals.
Why it happens
Induction of CYP3A4 by griseofulvin may increase docetaxel metabolism.
What to do
Avoid the combination if an alternative antifungal is available; otherwise monitor tumor response and toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Docetaxel
Frequently asked questions
Can I take Docetaxel with Griseofulvin?
MediHelp rates the interaction as moderate. Docetaxel and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may lower docetaxel exposure and reduce its antitumor effect. The magnitude is uncertain.
How serious is the interaction between Docetaxel and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative antifungal is available; otherwise monitor tumor response and toxicity.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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