Drug interactions
Docetaxel + Nefazodone
Severity: Major
Docetaxel and Nefazodone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone potently inhibits CYP3A4, the main route of docetaxel elimination. Docetaxel exposure may increase, raising the risk of neutropenia, fluid retention and other toxicity.
What this interaction means in plain words
Docetaxel and Nefazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Nefazodone inhibits CYP3A4-mediated docetaxel metabolism.
What to do
Use an antidepressant with minimal CYP3A4 inhibition instead. If nefazodone cannot be stopped, monitor blood counts closely and consider docetaxel dose reduction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Docetaxel
Frequently asked questions
Can I take Docetaxel with Nefazodone?
MediHelp rates the interaction as major. Docetaxel and Nefazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nefazodone potently inhibits CYP3A4, the main route of docetaxel elimination. Docetaxel exposure may increase, raising the risk of neutropenia, fluid retention and other toxicity.
How serious is the interaction between Docetaxel and Nefazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an antidepressant with minimal CYP3A4 inhibition instead. If nefazodone cannot be stopped, monitor blood counts closely and consider docetaxel dose reduction.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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