Drug interactions
Docetaxel + Olaparib
Severity: Moderate
Docetaxel and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause myelosuppression, and combined use can intensify and prolong neutropenia, anemia and thrombocytopenia.
What this interaction means in plain words
Docetaxel and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Additive pharmacodynamic bone marrow toxicity.
What to do
Monitor complete blood counts regularly and adjust or delay doses of either drug when significant cytopenias occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Docetaxel with Olaparib?
MediHelp rates the interaction as moderate. Docetaxel and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause myelosuppression, and combined use can intensify and prolong neutropenia, anemia and thrombocytopenia.
How serious is the interaction between Docetaxel and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and adjust or delay doses of either drug when significant cytopenias occur.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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