Drug interactions
Docetaxel + Quinupristin / dalfopristin
Severity: Moderate
Docetaxel and Quinupristin / dalfopristin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise docetaxel exposure, increasing the risk of myelosuppression and other toxicities. It is used for short courses of serious infection.
What this interaction means in plain words
Docetaxel and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4, reducing docetaxel metabolism.
What to do
Consider an alternative antibiotic where appropriate. If combined, monitor blood counts and docetaxel toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Frequently asked questions
Can I take Docetaxel with Quinupristin / dalfopristin?
MediHelp rates the interaction as moderate. Docetaxel and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may raise docetaxel exposure, increasing the risk of myelosuppression and other toxicities. It is used for short courses of serious infection.
How serious is the interaction between Docetaxel and Quinupristin / dalfopristin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic where appropriate. If combined, monitor blood counts and docetaxel toxicity.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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