Drug interactions
Donepezil + Dosulepin
Severity: Moderate
Donepezil and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a tricyclic antidepressant with substantial anticholinergic activity that opposes donepezil's effect. This may reduce cognitive benefit and worsen confusion, and both drugs can affect cardiac conduction.
What this interaction means in plain words
Donepezil and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Dosulepin belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism of cholinesterase inhibition by antimuscarinic activity.
What to do
Prefer a less anticholinergic antidepressant such as an SSRI in patients on donepezil. If combined, monitor cognition, heart rate and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Donepezil with Dosulepin?
MediHelp rates the interaction as moderate. Donepezil and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a tricyclic antidepressant with substantial anticholinergic activity that opposes donepezil's effect. This may reduce cognitive benefit and worsen confusion, and both drugs can affect cardiac conduction.
How serious is the interaction between Donepezil and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a less anticholinergic antidepressant such as an SSRI in patients on donepezil. If combined, monitor cognition, heart rate and ECG.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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