Drug interactions
Donepezil + Entrectinib
Severity: Major
Donepezil and Entrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and donepezil is associated with QT prolongation and torsades. Co-use increases arrhythmia risk, particularly with electrolyte disturbance or bradycardia.
What this interaction means in plain words
Donepezil and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Donepezil belongs to Central Nervous System; Entrectinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Avoid if possible. If both are needed, monitor ECG and electrolytes and adjust or interrupt entrectinib if QTc rises markedly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Donepezil with Entrectinib?
MediHelp rates the interaction as major. Donepezil and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib can prolong the QT interval, and donepezil is associated with QT prolongation and torsades. Co-use increases arrhythmia risk, particularly with electrolyte disturbance or bradycardia.
How serious is the interaction between Donepezil and Entrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If both are needed, monitor ECG and electrolytes and adjust or interrupt entrectinib if QTc rises markedly.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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