Drug interactions
Donepezil + Eribulin
Severity: Major
Donepezil and Eribulin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and donepezil has also been linked to QT prolongation and torsades de pointes. Using both increases the likelihood of a clinically significant arrhythmia.
What this interaction means in plain words
Donepezil and Eribulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Donepezil belongs to Central Nervous System; Eribulin belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities before starting. Monitor the ECG periodically during eribulin therapy, or consider an alternative to donepezil.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Apozyl 10 mg Orodispersible Tablets - SmPC sections 4.3/4.5 (class statement: other medicinal products known to prolong the QTc interval; "Caution is advised when donepezil is used in combination with other medicinal products known to prolong the QTc interval and clinical monitoring(ECG) may be req… — electronic medicines compendium (UK SmPC)
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Eribulin
Frequently asked questions
Can I take Donepezil with Eribulin?
MediHelp rates the interaction as major. Donepezil and Eribulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eribulin can prolong the QT interval, and donepezil has also been linked to QT prolongation and torsades de pointes. Using both increases the likelihood of a clinically significant arrhythmia.
How serious is the interaction between Donepezil and Eribulin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities before starting. Monitor the ECG periodically during eribulin therapy, or consider an alternative to donepezil.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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