Drug interactions
Donepezil + Fesoterodine
Severity: Moderate
Donepezil and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil increases cholinergic activity while fesoterodine blocks muscarinic receptors, so each can reduce the benefit of the other. Antimuscarinics may blunt cognitive benefit in dementia, and donepezil can worsen urinary urgency or incontinence.
What this interaction means in plain words
Donepezil and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Fesoterodine belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism between a cholinesterase inhibitor and a muscarinic antagonist.
What to do
Avoid combining where possible; if an antimuscarinic is needed, monitor cognition and urinary symptoms and consider the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Fesoterodine?
MediHelp rates the interaction as moderate. Donepezil and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil increases cholinergic activity while fesoterodine blocks muscarinic receptors, so each can reduce the benefit of the other. Antimuscarinics may blunt cognitive benefit in dementia, and donepezil can worsen urinary urgency or incontinence.
How serious is the interaction between Donepezil and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if an antimuscarinic is needed, monitor cognition and urinary symptoms and consider the lowest effective dose.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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