Drug interactions
Donepezil + Foscarnet
Severity: Moderate
Donepezil and Foscarnet: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil is associated with QT prolongation and torsades de pointes, and foscarnet electrolyte disturbances can add to the risk. Donepezil may also cause bradycardia, further predisposing to arrhythmia.
What this interaction means in plain words
Donepezil and Foscarnet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Foscarnet belongs to Anti Virals.
Why it happens
Additive QT prolongation with electrolyte disturbance and cholinesterase-mediated bradycardia.
What to do
Monitor ECG and electrolytes and watch for bradycardia or syncope during foscarnet therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Foscarnet?
MediHelp rates the interaction as moderate. Donepezil and Foscarnet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil is associated with QT prolongation and torsades de pointes, and foscarnet electrolyte disturbances can add to the risk. Donepezil may also cause bradycardia, further predisposing to arrhythmia.
How serious is the interaction between Donepezil and Foscarnet?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes and watch for bradycardia or syncope during foscarnet therapy.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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