Drug interactions
Donepezil + Nelfinavir
Severity: Minor
Donepezil and Nelfinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4, which participates in donepezil metabolism, so donepezil exposure may increase modestly. Cholinergic effects such as bradycardia and nausea may become more evident.
What this interaction means in plain words
Donepezil and Nelfinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Donepezil belongs to Central Nervous System; Nelfinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated donepezil metabolism by nelfinavir.
What to do
No routine adjustment; monitor pulse and GI symptoms after starting nelfinavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Donepezil with Nelfinavir?
MediHelp rates the interaction as minor. Donepezil and Nelfinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nelfinavir inhibits CYP3A4, which participates in donepezil metabolism, so donepezil exposure may increase modestly. Cholinergic effects such as bradycardia and nausea may become more evident.
How serious is the interaction between Donepezil and Nelfinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor pulse and GI symptoms after starting nelfinavir.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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