Drug interactions
Donepezil + Rufinamide
Severity: Minor
Donepezil and Rufinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak CYP3A4 inducer and might slightly lower donepezil levels. The effect is probably small and of limited clinical significance.
What this interaction means in plain words
Donepezil and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Donepezil belongs to Central Nervous System; Rufinamide belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by rufinamide increases donepezil metabolism.
What to do
No adjustment needed; monitor cognitive response if therapy is long-term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Donepezil with Rufinamide?
MediHelp rates the interaction as minor. Donepezil and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak CYP3A4 inducer and might slightly lower donepezil levels. The effect is probably small and of limited clinical significance.
How serious is the interaction between Donepezil and Rufinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; monitor cognitive response if therapy is long-term.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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