Drug interactions
Donepezil + Salbutamol
Severity: Moderate
Donepezil and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil can prolong the QT interval and cause bradycardia, while salbutamol may add to QT prolongation and lower potassium. Risk of arrhythmia is raised mainly in patients with other cardiac risk factors.
What this interaction means in plain words
Donepezil and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia contributing.
What to do
Monitor ECG and electrolytes in patients with cardiac disease who need regular or high-dose salbutamol with donepezil. Occasional inhaled use usually needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Salbutamol?
MediHelp rates the interaction as moderate. Donepezil and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil can prolong the QT interval and cause bradycardia, while salbutamol may add to QT prolongation and lower potassium. Risk of arrhythmia is raised mainly in patients with other cardiac risk factors.
How serious is the interaction between Donepezil and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with cardiac disease who need regular or high-dose salbutamol with donepezil. Occasional inhaled use usually needs no change.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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