Drug interactions
Donepezil + Telavancin
Severity: Moderate
Donepezil and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil is associated with QT prolongation, torsades de pointes and bradycardia, and telavancin may add to the QT effect. Elderly patients with dementia may be especially vulnerable.
What this interaction means in plain words
Donepezil and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Telavancin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, with donepezil-related bradycardia increasing risk.
What to do
Obtain a baseline ECG and monitor heart rate and QTc during co-therapy. Correct electrolytes and consider pausing donepezil if QT lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Telavancin?
MediHelp rates the interaction as moderate. Donepezil and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil is associated with QT prolongation, torsades de pointes and bradycardia, and telavancin may add to the QT effect. Elderly patients with dementia may be especially vulnerable.
How serious is the interaction between Donepezil and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate and QTc during co-therapy. Correct electrolytes and consider pausing donepezil if QT lengthens significantly.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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