Drug interactions
Donepezil transdermal + Fesoterodine
Severity: Moderate
Donepezil transdermal and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil increases cholinergic activity while fesoterodine blocks muscarinic receptors, so each may blunt the other's effect. This may reduce control of overactive bladder or lessen cognitive benefit, and fesoterodine may worsen cognition in dementia.
What this interaction means in plain words
Donepezil transdermal and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between a cholinesterase inhibitor and a muscarinic antagonist.
What to do
Avoid the combination where possible and consider a non-anticholinergic bladder option such as a beta-3 agonist; if used, monitor cognition and urinary symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Donepezil transdermal with Fesoterodine?
MediHelp rates the interaction as moderate. Donepezil transdermal and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil increases cholinergic activity while fesoterodine blocks muscarinic receptors, so each may blunt the other's effect. This may reduce control of overactive bladder or lessen cognitive benefit, and fesoterodine may worsen cognition in dementia.
How serious is the interaction between Donepezil transdermal and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider a non-anticholinergic bladder option such as a beta-3 agonist; if used, monitor cognition and urinary symptoms.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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