Drug interactions
Dong quai + Meclofenamic acid
Severity: Moderate
Dong quai and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamic acid inhibits platelet function and can injure the gastric mucosa, while dong quai contains coumarin-type constituents that may have antiplatelet or anticoagulant activity. Taken together they may raise the risk of bruising and bleeding, including gastrointestinal bleeding. The evidence consists mostly of theoretical reasoning and isolated reports.
What this interaction means in plain words
Dong quai and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on hemostasis: NSAID-mediated COX-1 platelet inhibition combined with possible coumarin-like activity of dong quai.
What to do
Ask patients about herbal use and advise against routine combination. If both are continued, monitor for bleeding signs and check INR if the patient also takes warfarin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Dong quai with Meclofenamic acid?
MediHelp rates the interaction as moderate. Dong quai and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamic acid inhibits platelet function and can injure the gastric mucosa, while dong quai contains coumarin-type constituents that may have antiplatelet or anticoagulant activity. Taken together they may raise the risk of bruising and bleeding, including gastrointestinal bleeding. The evidence consists mostly of theoretical reasoning and isolated reports.
How serious is the interaction between Dong quai and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal use and advise against routine combination. If both are continued, monitor for bleeding signs and check INR if the patient also takes warfarin.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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