Drug interactions
Dopexamine + Imipramine
Severity: Moderate
Dopexamine and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of catecholamine-like agents such as dopexamine, which inhibits norepinephrine uptake itself. This may result in tachycardia, arrhythmia or blood pressure swings.
What this interaction means in plain words
Dopexamine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Imipramine blocks neuronal catecholamine reuptake, enhancing and prolonging adrenergic stimulation.
What to do
Monitor ECG, heart rate and blood pressure continuously during dopexamine infusion in patients taking imipramine, and titrate the dose cautiously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Dopexamine with Imipramine?
MediHelp rates the interaction as moderate. Dopexamine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of catecholamine-like agents such as dopexamine, which inhibits norepinephrine uptake itself. This may result in tachycardia, arrhythmia or blood pressure swings.
How serious is the interaction between Dopexamine and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and blood pressure continuously during dopexamine infusion in patients taking imipramine, and titrate the dose cautiously.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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