Drug interactions
Dopexamine + Isocarboxazid
Severity: Contraindicated
Dopexamine and Isocarboxazid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopexamine is a catecholamine-like agent, and MAO inhibition blocks catecholamine breakdown, which can amplify its cardiovascular effects. This may produce marked hypertension, tachycardia and arrhythmias.
What this interaction means in plain words
Dopexamine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition reduces catecholamine degradation and increases adrenergic stimulation, producing additive pressor effects.
What to do
Avoid the combination and allow a washout of at least 14 days after stopping isocarboxazid before using dopexamine. Choose a non-adrenergic alternative where possible.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dopexamine and Isocarboxazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Dopexamine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Dopexamine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dopexamine is a catecholamine-like agent, and MAO inhibition blocks catecholamine breakdown, which can amplify its cardiovascular effects. This may produce marked hypertension, tachycardia and arrhythmias.
How serious is the interaction between Dopexamine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and allow a washout of at least 14 days after stopping isocarboxazid before using dopexamine. Choose a non-adrenergic alternative where possible.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
