Drug interactions
Dopexamine + Nortriptyline
Severity: Moderate
Dopexamine and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopexamine is a catecholamine whose uptake is blocked by tricyclics, potentially exaggerating its cardiovascular effects. This can lead to tachycardia, hypertension and arrhythmia.
What this interaction means in plain words
Dopexamine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of neuronal catecholamine reuptake by nortriptyline alters sympathomimetic response.
What to do
Titrate dopexamine cautiously with continuous hemodynamic and ECG monitoring. Reduce the infusion rate if tachyarrhythmia or hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Dopexamine with Nortriptyline?
MediHelp rates the interaction as moderate. Dopexamine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dopexamine is a catecholamine whose uptake is blocked by tricyclics, potentially exaggerating its cardiovascular effects. This can lead to tachycardia, hypertension and arrhythmia.
How serious is the interaction between Dopexamine and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate dopexamine cautiously with continuous hemodynamic and ECG monitoring. Reduce the infusion rate if tachyarrhythmia or hypertension develops.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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