Drug interactions
Dopexamine + Phenelzine
Severity: Contraindicated
Dopexamine and Phenelzine: contraindicated interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopexamine is a catecholamine whose effects are potentiated when MAO is inhibited. This can cause exaggerated pressor and cardiac stimulation, with hypertensive crisis and tachyarrhythmias.
What this interaction means in plain words
Dopexamine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition reduces catecholamine metabolism and increases the amount of sympathomimetic reaching adrenergic receptors.
What to do
Avoid the combination; use an alternative inotrope with continuous hemodynamic monitoring if essential, after specialist advice.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Dopexamine with Phenelzine?
MediHelp rates the interaction as contraindicated. Dopexamine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dopexamine is a catecholamine whose effects are potentiated when MAO is inhibited. This can cause exaggerated pressor and cardiac stimulation, with hypertensive crisis and tachyarrhythmias.
How serious is the interaction between Dopexamine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative inotrope with continuous hemodynamic monitoring if essential, after specialist advice.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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