Drug interactions
Dopexamine + Propranolol
Severity: Moderate
Dopexamine and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol antagonizes the beta-2 and beta-1 agonist effects of dopexamine, reducing its vasodilator and inotropic benefit. Dopexamine's hemodynamic effect may be unpredictable in a beta-blocked patient.
What this interaction means in plain words
Dopexamine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive beta-adrenoceptor antagonism by propranolol opposes the beta-agonist activity of dopexamine.
What to do
Monitor blood pressure, heart rate and perfusion closely and titrate dopexamine to response. Consider whether the beta blocker should be held in acute hemodynamic support.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Dopexamine with Propranolol?
MediHelp rates the interaction as moderate. Dopexamine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol antagonizes the beta-2 and beta-1 agonist effects of dopexamine, reducing its vasodilator and inotropic benefit. Dopexamine's hemodynamic effect may be unpredictable in a beta-blocked patient.
How serious is the interaction between Dopexamine and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and perfusion closely and titrate dopexamine to response. Consider whether the beta blocker should be held in acute hemodynamic support.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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