Drug interactions
Dosulepin + Meclizine
Severity: Moderate
Dosulepin and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a tricyclic with strong antimuscarinic and sedative effects, and meclizine adds both. The combination raises the risk of dry mouth, constipation, urinary retention, blurred vision, confusion and drowsiness.
What this interaction means in plain words
Dosulepin and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Meclizine belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade and H1-mediated sedation.
What to do
Use the lowest effective meclizine dose for the shortest time and monitor for anticholinergic toxicity, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclizine
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Meclizine?
MediHelp rates the interaction as moderate. Dosulepin and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a tricyclic with strong antimuscarinic and sedative effects, and meclizine adds both. The combination raises the risk of dry mouth, constipation, urinary retention, blurred vision, confusion and drowsiness.
How serious is the interaction between Dosulepin and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective meclizine dose for the shortest time and monitor for anticholinergic toxicity, especially in older adults.
What other medicines interact with Meclizine?
MediHelp also lists interactions of Meclizine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Meclizine page.
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