Drug interactions
Dosulepin + Olanzapine
Severity: Moderate
Dosulepin and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, so use together can increase drowsiness and psychomotor impairment. Dosulepin is a tricyclic with anticholinergic, hypotensive and QT-prolonging properties, so combined use adds to anticholinergic burden and cardiac risk.
What this interaction means in plain words
Dosulepin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects, with additive effects on cardiac conduction.
What to do
Start at low doses, monitor sedation, blood pressure and anticholinergic effects, and consider an ECG in patients with cardiac disease or older age. Counsel about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Olanzapine?
MediHelp rates the interaction as moderate. Dosulepin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, so use together can increase drowsiness and psychomotor impairment. Dosulepin is a tricyclic with anticholinergic, hypotensive and QT-prolonging properties, so combined use adds to anticholinergic burden and cardiac risk.
How serious is the interaction between Dosulepin and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start at low doses, monitor sedation, blood pressure and anticholinergic effects, and consider an ECG in patients with cardiac disease or older age. Counsel about driving.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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