Drug interactions
Dosulepin + Pyridostigmine
Severity: Moderate
Dosulepin and Pyridostigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin, a tricyclic antidepressant, has marked anticholinergic activity that can oppose pyridostigmine. This may reduce its benefit and can worsen myasthenic symptoms; tricyclics may also cause sedation and weakness.
What this interaction means in plain words
Dosulepin and Pyridostigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Pyridostigmine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between muscarinic blockade and cholinesterase inhibition.
What to do
Monitor myasthenic symptoms and adjust the pyridostigmine dose if control worsens. Consider a less anticholinergic antidepressant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pyridostigmine
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Pyridostigmine?
MediHelp rates the interaction as moderate. Dosulepin and Pyridostigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin, a tricyclic antidepressant, has marked anticholinergic activity that can oppose pyridostigmine. This may reduce its benefit and can worsen myasthenic symptoms; tricyclics may also cause sedation and weakness.
How serious is the interaction between Dosulepin and Pyridostigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor myasthenic symptoms and adjust the pyridostigmine dose if control worsens. Consider a less anticholinergic antidepressant.
What other medicines interact with Pyridostigmine?
MediHelp also lists interactions of Pyridostigmine with, for example, Echothiophate iodide, Huperzine a, Neostigmine. The full list is on the Pyridostigmine page.
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