Drug interactions
Dosulepin + Triprolidine
Severity: Moderate
Dosulepin and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant with significant anticholinergic activity. With triprolidine it causes additive drowsiness and anticholinergic effects including dry mouth, constipation, urinary retention and confusion.
What this interaction means in plain words
Dosulepin and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Monitor for oversedation and anticholinergic toxicity, especially in older adults. Prefer a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Triprolidine?
MediHelp rates the interaction as moderate. Dosulepin and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant with significant anticholinergic activity. With triprolidine it causes additive drowsiness and anticholinergic effects including dry mouth, constipation, urinary retention and confusion.
How serious is the interaction between Dosulepin and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic toxicity, especially in older adults. Prefer a non-sedating antihistamine.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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