Drug interactions
Doxapram + Epinephrine
Severity: Moderate
Doxapram and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxapram can raise blood pressure and heart rate through sympathetic stimulation. Combined with epinephrine, hypertension and arrhythmias may be amplified.
What this interaction means in plain words
Doxapram and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxapram belongs to Central Nervous System; Epinephrine belongs to Endocrine.
Why it happens
Additive pressor and sympathomimetic effects.
What to do
Monitor blood pressure and heart rhythm continuously, and reduce the epinephrine dose if hypertension or tachyarrhythmia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Other interactions of Doxapram
- Desflurane + Doxapram Major
- Dextroamphetamine + Doxapram Major
- Doxapram + Isocarboxazid Major
- Doxapram + Ketamine Major
- Doxapram + Linezolid Major
- Doxapram + Lisdexamfetamine Major
Frequently asked questions
Can I take Doxapram with Epinephrine?
MediHelp rates the interaction as moderate. Doxapram and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxapram can raise blood pressure and heart rate through sympathetic stimulation. Combined with epinephrine, hypertension and arrhythmias may be amplified.
How serious is the interaction between Doxapram and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rhythm continuously, and reduce the epinephrine dose if hypertension or tachyarrhythmia develops.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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