Drug interactions
Doxapram + Theophylline
Severity: Moderate
Doxapram and Theophylline: moderate interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs stimulate the central nervous system and can add to each other's effects. Combined use may cause agitation, tremor, tachycardia, arrhythmias or seizures. This matters especially in acute respiratory failure where both may be used.
What this interaction means in plain words
Doxapram and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxapram belongs to Central Nervous System; Theophylline belongs to Respiratory.
Why it happens
Additive CNS and cardiovascular stimulation.
What to do
Monitor heart rhythm, blood pressure and neurological status, and use the lowest effective doses of both drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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References
- Dopram - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Doxapram
- Desflurane + Doxapram Major
- Dextroamphetamine + Doxapram Major
- Doxapram + Isocarboxazid Major
- Doxapram + Ketamine Major
- Doxapram + Linezolid Major
- Doxapram + Lisdexamfetamine Major
Frequently asked questions
Can I take Doxapram with Theophylline?
MediHelp rates the interaction as moderate. Doxapram and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs stimulate the central nervous system and can add to each other's effects. Combined use may cause agitation, tremor, tachycardia, arrhythmias or seizures. This matters especially in acute respiratory failure where both may be used.
How serious is the interaction between Doxapram and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rhythm, blood pressure and neurological status, and use the lowest effective doses of both drugs.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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