Drug interactions
Doxazosin + Flurbiprofen
Severity: Moderate
Doxazosin and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen may reduce the antihypertensive efficacy of doxazosin by causing fluid retention. The effect is usually modest but can matter in patients with poorly controlled hypertension.
What this interaction means in plain words
Doxazosin and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Prostaglandin synthesis inhibition leads to sodium and water retention.
What to do
Monitor blood pressure during concurrent use and adjust doxazosin as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Doxazosin with Flurbiprofen?
MediHelp rates the interaction as moderate. Doxazosin and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen may reduce the antihypertensive efficacy of doxazosin by causing fluid retention. The effect is usually modest but can matter in patients with poorly controlled hypertension.
How serious is the interaction between Doxazosin and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during concurrent use and adjust doxazosin as needed.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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