Drug interactions
Doxazosin + Fosinopril
Severity: Moderate
Doxazosin and Fosinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together they can cause an exaggerated blood pressure drop, particularly after the first dose or after dose increases. Dizziness and syncope are the main concerns.
What this interaction means in plain words
Doxazosin and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Fosinopril belongs to Cardiovascular.
Why it happens
Additive vasodilation from alpha-1 blockade and ACE inhibition.
What to do
Start the added drug at a low dose at bedtime and monitor blood pressure and orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Doxazosin with Fosinopril?
MediHelp rates the interaction as moderate. Doxazosin and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Together they can cause an exaggerated blood pressure drop, particularly after the first dose or after dose increases. Dizziness and syncope are the main concerns.
How serious is the interaction between Doxazosin and Fosinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start the added drug at a low dose at bedtime and monitor blood pressure and orthostatic symptoms.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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