Drug interactions
Doxazosin + Ibuprofen
Severity: Moderate
Doxazosin and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen can blunt the antihypertensive effect of doxazosin by causing sodium and fluid retention. Loss of blood pressure control may occur with regular use.
What this interaction means in plain words
Doxazosin and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Ibuprofen belongs to Musculoskeletal.
Why it happens
Inhibition of prostaglandin synthesis reduces renal sodium excretion and vasodilation.
What to do
Monitor blood pressure when ibuprofen is started or stopped and adjust doxazosin if needed; limit NSAID dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Doxazosin with Ibuprofen?
MediHelp rates the interaction as moderate. Doxazosin and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen can blunt the antihypertensive effect of doxazosin by causing sodium and fluid retention. Loss of blood pressure control may occur with regular use.
How serious is the interaction between Doxazosin and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when ibuprofen is started or stopped and adjust doxazosin if needed; limit NSAID dose and duration.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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